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An ALE meta-analysis of the functional correlates of word and pseudoword repetition.
Poster C9 in Poster Session C, Wednesday, October 25, 10:15 am - 12:00 pm CEST, Espace Vieux-Port
María José Torres Prioris1,2,3,4, Ariane Hohl1, Marcelo L. Berthier1,3, Diana López-Barroso1,2,3; 1Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, C/Marqués de Beccaria 3, 29010, Malaga, Spain., 2Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology, University of Malaga, C/ Doctor Ortiz Ramos, 12, Ampliación Teatinos, 29010, Malaga, Spain., 3Instituto de Investigación Biomédica de Málaga – IBIMA, Malaga, Spain., 4Wellcome Centre for Human Neuroimaging. University College London (UCL).
Introduction. Verbal repetition abilities are of utmost importance, playing a vital role in various advanced linguistic functions, including language acquisition and language recovery after a stroke. Although repeating back a verbal sequence appears to be a straightforward task, it actually requires the involvement of several intricate subprocesses to successfully achieve it. Nevertheless, our understanding of the brain regions involved in repetition remains limited, though the repetition of known and unknown stimuli seems to rely on distinct processing pathways1,2. Objectives: The primary aim of this study is to determine the precise brain regions engaged in verbal repetition among neurotypical adults. First, we examine the neural correlates associated with repetition as a general linguistic process. Additionally, we conducted separate analyses to disentangle the pattern of activation associated with the repetition of stimuli with semantic content (words) and without (pseudowords). Lastly, our objective was to investigate the varying roles played by the right and left hemispheres of the brain in repetition processes. Methods: A systematic literature search on four databases was conducted. Twenty-three articles including 25 independent experiments were found to fulfill the inclusion criteria. Three main activation likelihood estimation (ALE) meta-analyses were conducted. The first analysis included all the detected studies (ALE 1: general repetition; n = 25), pooling together varying forms of verbal repetition. After, two complementary analyses were added to capture brain regions involved in the repetition of different stimuli: ALE 2 included only contrasts containing word repetition (n = 17); while ALE 3 included only those contrasts tapping pseudoword repetition (n = 10). Lastly, laterality indices were computed to assess the contribution of the left and right hemispheres in the three ALE activation maps. Results: Left hemispheric perisylvian areas, namely the superior temporal gyrus and premotor area, were engaged in all processes. However, pseudoword repetition was associated with greater activation in the temporal and premotor areas compared to word repetition, and with a left-ward activation pattern in the inferior frontal gyrus (IFG); while word repetition revealed greater activation in the left medial frontal cortex and right temporal areas. Repetition of stimuli with semantic content was associated with a more symmetrical activation of the IFG. On a hemispheric level, both repetition processes showed symmetrical brain activation. Conclusions: This is the first meta-analysis exploring the overlap between functional studies employing different verbal repetition tasks. These consistent activation patterns across experiments can be integrated into current models of language processing. References: 1Yoo, S., Chung, J. Y., Jeon, H. A., Lee, K. M., Kim, Y. B., & Cho, Z. H. (2012). Dual routes for verbal repetition: Articulation-based and acoustic–phonetic codes for pseudoword and word repetition, respectively. Brain and language, 122(1), 1-10., 2Saur, D., Kreher, B. W., Schnell, S., Kümmerer, D., Kellmeyer, P., Vry, M. S., ... & Weiller, C. (2008). Ventral and dorsal pathways for language. Proceedings of the national academy of Sciences, 105(46), 18035-18040.
Topic Areas: Language Production,